Article

Human adenylyl cyclase 9 is auto-stimulated by its isoform-specific C-terminal domain and equipped with paradigm-switching mechanisms

2022-06-05

Abstract excerpt

Human transmembrane adenylyl cyclase 9 (AC9) is not regulated by heterotrimeric G proteins. Key to the resistance to stimulation by Gs-coupled receptors (GsR) is auto-inhibition by the COOH-terminal domain (C2b). The present study investigated the role of the C2b domain in the regulation of cyclic AMP production by AC9 in HEK293FT cells expressing the Glosensor22F cyclic AMP-reporter protein. Surprisingly, we foun...

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Literature Corpus work: 99f13e8d-7027-53a4-877b-63cb43acfa1a
DOI: 10.1101/2022.06.05.494885

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