Article
Two domains are critical for the nuclear localization of soluble adenylyl cyclase.
Biochimie - 1 Jan 2000
Feng Qiping, Zhang Yongwei, Li Yunfeng, Liu Zhuo, Zuo Jin, Fang Fude
Abstract excerpt
Soluble adenylyl cyclase (sAC) is a newly identified source of cyclic adenosine 3',5'-monophosphate (cAMP). Unlike the well-known transmembrane adenylyl cyclases (tmACs), sAC locates to the nucleus, mitochondria and microtubules. For most cAMP-signaling microdomains, there is always an AC nearby, for example tmAC. But it was until the discovery of sAC that there was not known cAMP resource in the nucleus. sAC...
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