Article
The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement.
The EMBO journal - 3 Sept 2001
Davodeau F, Difilippantonio M, Roldan E, Malissen M, Casanova J L, Couedel C, Morcet J F, Merkenschlager M, Nussenzweig A, Bonneville M, Malissen B
Abstract excerpt
The T-cell receptor (TCR) alpha locus is thought to undergo multiple cycles of secondary rearrangements that maximize the generation of alphabeta T cells. Taking advantage of the nucleotide sequence of the human Valpha and Jalpha segments, we undertook a locus-wide analysis of TCRalpha gene rearrangements in human alphabeta T-cell clones. In most clones, ValphaJalpha rearrangements occurred on both homologous...
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