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Article

Ordered and coordinated rearrangement of the TCR alpha locus: role of secondary rearrangement in thymic selection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2001

Huang C, Kanagawa O

Abstract excerpt

The Ag receptor of the T lymphocyte is composed of an alphabeta heterodimer. Both alpha- and beta-chains are products of the somatic rearrangement of V(D)J segments encoded on the respective loci. During T cell development, beta-chain rearrangement precedes alpha-chain rearrangement. The mechanism of allelic exclusion ensures the expression of a single beta-chain in each T cell, whereas a large number of T cells...

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Share to Mice, Inbred BALB C

Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

Identifiers

PMID: 11160321
DOI: 10.4049/jimmunol.166.4.2597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ordered and coordinated rearrangement of the TCR alpha locus: role of secondary rearrangement in thymic selection.PMID 11160321Read ↗

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