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Article

A model for TCR gene segment use.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2006

Warmflash Aryeh, Dinner Aaron R

Abstract excerpt

The TCR alpha-chain is assembled by somatic recombination of variable (V) and joining (J) gene segments at the CD4+ CD8+ stage of development. In this study, we present the first analytical model for deletional rearrangement and show that it is consistent with almost all available data on Valpha Jalpha use in mice and humans. A key feature of the model is that both "local" and "express service" models of...

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Identifiers

PMID: 16951348
DOI: 10.4049/jimmunol.177.6.3857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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