Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.

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Article

Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1998

Alam S M, Gascoigne N R

Abstract excerpt

We have previously shown that phenotypic allelic exclusion of TCR alpha-chain is functional only in mature thymocytes. A significant proportion of immature thymocytes (TCRlow) express more than one cell surface alpha-chain, but mature thymocytes (TCRhigh) show phenotypic allelic exclusion and express only a single alpha-chain. We have analyzed thymocytes for both surface and intracellular alpha-chain expression...

Topics

Alleles
Animals
Cell Differentiation
Cell Membrane
Cytoplasm
Gene Expression Regulation, Developmental
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Biological
Phenotype
T-Lymphocytes
Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 9558094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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