Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.

Immunology today - 1 Aug 1992

Malissen M, Trucy J, Jouvin-Marche E, Cazenave P A, Scollay R, Malissen B

Abstract excerpt

Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Clone Cells
Share to DNA Nucleotidyltransferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Mice, Transgenic

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to T-Lymphocytes

Source

Identifiers

PMID: 1324691
DOI: 10.1016/0167-5699(92)90044-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.PMID 1324691Read ↗

Ordered and coordinated rearrangement of the TCR alpha locus: role of secondary rearrangement in thymic selection.Semantic proximity Read ↗

Long-Range Control of V(D)J Recombination & Allelic Exclusion: Modeling Views.Semantic proximity Read ↗

Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment.Semantic proximity Read ↗

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.Semantic proximity Read ↗

Exclusion and inclusion of alpha and beta T cell receptor alleles.Semantic proximity Read ↗

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.Semantic proximity Read ↗

Incomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice.Semantic proximity Read ↗

Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.Semantic proximity Read ↗

Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex.Semantic proximity Read ↗

Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.Semantic proximity Read ↗

Allelic exclusion of mouse T cell receptor alpha chains occurs at the time of thymocyte TCR up-regulation.Semantic proximity Read ↗

Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.