Article
Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.
Immunology today - 1 Aug 1992
Malissen M, Trucy J, Jouvin-Marche E, Cazenave P A, Scollay R, Malissen B
Abstract excerpt
Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with...
Topics
- Alleles
- Animals
- Clone Cells
- DNA Nucleotidyltransferases
- Gene Expression Regulation
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Mice
- Mice, Transgenic
- Receptors, Antigen, T-Cell, alpha-beta