Article
Preferential rearrangements of the T cell receptor-delta-deleting elements in human T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1997
Verschuren M C, Wolvers-Tettero I L, Breit T M, Noordzij J, van Wering E R, van Dongen J J
Abstract excerpt
The major part of the TCR-delta locus is flanked by the so-called TCR-delta-deleting elements deltaRec and psi(J)alpha, which preferentially rearrange to each other in human thymocytes. On the basis of our combined Southern blot and PCR analyses, we also identified the prominent deltaRec-Jalpha58...
Topics
- Alleles
- Base Sequence
- Blotting, Southern
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
- Humans
- Polymerase Chain Reaction
- Receptors, Antigen, T-Cell, gamma-delta
- Regulatory Sequences, Nucleic Acid
- Sequence Deletion
- T-Lymphocytes
- Thymus Gland
- Tumor Cells, Cultured