Article
Positive selection through a motif in the alphabeta T cell receptor.
Science (New York, N.Y.) - 7 Aug 1998
Bäckström B T, Müller U, Hausmann B, Palmer E
Abstract excerpt
The two lineages of T cells, alphabeta and gammadelta, differ in their developmental requirements: only alphabeta T cells require major histocompatibility complex recognition, a process known as positive selection. The alphabeta T cell receptor (TCR), but not its gammadelta counterpart, contains...
Topics
- Amino Acid Sequence
- Animals
- Antigen-Presenting Cells
- CD3 Complex
- CD4-Positive T-Lymphocytes
- Cell Lineage
- Cells, Cultured
- Histocompatibility Antigens Class II
- Ligands
- Lymphocyte Count
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Nude
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Receptor-CD3 Complex, Antigen, T-Cell