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Article

Positive selection through a motif in the alphabeta T cell receptor.

Science (New York, N.Y.) - 7 Aug 1998

Bäckström B T, Müller U, Hausmann B, Palmer E

Abstract excerpt

The two lineages of T cells, alphabeta and gammadelta, differ in their developmental requirements: only alphabeta T cells require major histocompatibility complex recognition, a process known as positive selection. The alphabeta T cell receptor (TCR), but not its gammadelta counterpart, contains a motif within the alpha-chain connecting peptide domain (alpha-CPM) that has been conserved over the last 500 million...

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Identifiers

PMID: 9694657
DOI: 10.1126/science.281.5378.835

Genes

CPM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Distinctive CD3 Heterodimeric Ectodomain Topologies Maximize Antigen-Triggered Activation of αβ T Cell ReceptorsSemantic proximity Read ↗

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