Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosomal excision of TCRdelta chain genes is dispensable for alphabeta T cell lineage commitment.

International immunology - 1 Mar 2005

Khor Bernard, Wehrly Tara D, Sleckman Barry P

Abstract excerpt

TCRbeta, delta and gamma chain genes are assembled and expressed in double-negative thymocytes prior to alphabeta or gammadelta T cell lineage commitment. Thus, cells committed to the alphabeta T cell lineage can possess completely assembled TCRdelta and/or TCRgamma chain genes. However, these genes are not expressed. TCRgamma chain gene expression may be silenced through the activity of a cis-acting silencer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Antigens, Differentiation
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor

Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Share to Gene Rearrangement, delta-Chain T-Cell Antigen Receptor

Share to T-Lymphocytes

Source

Identifiers

PMID: 15642954
DOI: 10.1093/intimm/dxh202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosomal excision of TCRdelta chain genes is dispensable for alphabeta T cell lineage commitment.PMID 15642954Read ↗

Characterization of TCR Gene Rearrangements During Adult Murine T Cell DevelopmentSemantic proximity Read ↗

Ordered and coordinated rearrangement of the TCR alpha locus: role of secondary rearrangement in thymic selection.Semantic proximity Read ↗

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.Semantic proximity Read ↗

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.Semantic proximity Read ↗

The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement.Semantic proximity Read ↗

Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes.Semantic proximity Read ↗

T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.Semantic proximity Read ↗

Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion.Semantic proximity Read ↗

TCR-beta chains derived from peripheral gammadelta T cells can take part in alphabeta T-cell development.Semantic proximity Read ↗

Allelic exclusion at the TCRbeta locus.Semantic proximity Read ↗

Mechanisms controlling termination of V-J recombination at the TCRgamma locus: implications for allelic and isotypic exclusion of TCRgamma chains.Semantic proximity Read ↗

Preferential rearrangements of the T cell receptor-delta-deleting elements in human T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.