Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pleiotropic changes controlled by the pre-T-cell receptor.

Current opinion in immunology - 1 Apr 1999

von Boehmer H, Aifantis I, Feinberg J, Lechner O, Saint-Ruf C, Walter U, Buer J, Azogui O

Abstract excerpt

The construction of various gene-deficient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of alphabeta lineage cells. A predominant role is occupied by the pre-TCR, which not only generates large numbers of alphabeta lineage cells but also controls TCRbeta allelic exclusion as well as commitment to the gammadelta lineage versus the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Precursors

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Antigen, T-Cell, gamma-delta

Source

Identifiers

PMID: 10322152
DOI: 10.1016/s0952-7915(99)80024-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pleiotropic changes controlled by the pre-T-cell receptor.PMID 10322152Read ↗

Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment.Semantic proximity Read ↗

The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.Semantic proximity Read ↗

TCRbeta transmembrane tyrosines are required for pre-TCR function.Semantic proximity Read ↗

Branching out to gain control: how the pre-TCR is linked to multiple functions.Semantic proximity Read ↗

The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants.Semantic proximity Read ↗

Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.Semantic proximity Read ↗

Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling.Semantic proximity Read ↗

Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development.Semantic proximity Read ↗

The impact of pre-T-cell receptor signals on gene expression in developing T cells.Semantic proximity Read ↗

The Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 action.Semantic proximity Read ↗

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.Semantic proximity Read ↗

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.