Pleiotropic changes controlled by the pre-T-cell receptor.

doi:10.1016/s0952-7915(99)80024-7

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Article

Pleiotropic changes controlled by the pre-T-cell receptor.

Current opinion in immunology - 1 Apr 1999

von Boehmer H, Aifantis I, Feinberg J, Lechner O, Saint-Ruf C, Walter U, Buer J, Azogui O

Abstract excerpt

The construction of various gene-deficient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of alphabeta lineage cells. A predominant role is occupied by the pre-TCR, which not only generates large numbers of alphabeta lineage cells but also controls TCRbeta allelic exclusion as well as commitment to the gammadelta lineage versus the...

Topics

Alleles
Animals
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Humans
Mice
Protein Precursors
Receptors, Antigen, T-Cell, alpha-beta
Receptors, Antigen, T-Cell, gamma-delta

Source

Open in PubMed

Identifiers

PMID: 10322152
DOI: 10.1016/s0952-7915(99)80024-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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