Article
Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2007
Hawwari Abbas, Krangel Michael S
Abstract excerpt
During the recombination of variable (V) and joining (J) gene segments at the T cell receptor alpha locus, a ValphaJalpha joint resulting from primary rearrangement can be replaced by subsequent rounds of secondary rearrangement that use progressively more 5' Valpha segments and progressively more 3' Jalpha segments. To understand the mechanisms that target secondary T cell receptor alpha recombination, we...
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