Article
Expression and combinatorial diversity of germ line-encoded T cell receptor V genes in human peripheral blood T cells.
Cellular immunology - 15 Apr 1992
Imberti L, Sottini A, Primi D
Abstract excerpt
The potential diversity of the T cell receptor (TcR) is defined by the combinational expression of variable segments and by mechanisms that insert or delete nucleotides at the junctional regions. The available repertoire is strongly influenced by negative and positive selection events. To study whether the diversity of the human T cell receptor of peripheral T cells is further restricted by the interaction...
Topics
- Electrophoresis, Polyacrylamide Gel
- Ethidium
- Gene Expression
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genetic Variation
- Hematopoietic Stem Cells
- Humans
- Immunoenzyme Techniques
- Polymerase Chain Reaction