Expression and combinatorial diversity of germ line-encoded T cell receptor V genes in human peripheral blood T cells.

Abstract excerpt

The potential diversity of the T cell receptor (TcR) is defined by the combinational expression of variable segments and by mechanisms that insert or delete nucleotides at the junctional regions. The available repertoire is strongly influenced by negative and positive selection events. To study whether the diversity of the human T cell receptor of peripheral T cells is further restricted by the interaction...

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