Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation.

doi:10.1038/ng939

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Article

Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation.

Nature genetics - 1 Sept 2002

Lee Jeannie T

Abstract excerpt

Tsix controls X-chromosome inactivation (XCI) by blocking the accumulation of Xist RNA on the future active X chromosome. Deleting Tsix on one X chromosome (X(Delta)X) skews XCI toward the mutated X chromosome in the female soma. Here I have generated homozygous Tsix-null mice (X(Delta)X(Delta)) to test how deleting the second allele affects the choice of XCI. Homozygosity leads to extremely low fertility and...

Topics

Animals
Crosses, Genetic
Dosage Compensation, Genetic
Female
Homozygote
Male
Mice
Mice, Inbred C57BL
Mutation
RNA, Antisense
RNA, Long Noncoding
RNA, Untranslated
Sex Ratio
Transcription Factors
Trophoblasts
X Chromosome

Source

Open in PubMed

Identifiers

PMID: 12145659
DOI: 10.1038/ng939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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