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Article

Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation.

Nature genetics - 1 Sept 2002

Lee Jeannie T

Abstract excerpt

Tsix controls X-chromosome inactivation (XCI) by blocking the accumulation of Xist RNA on the future active X chromosome. Deleting Tsix on one X chromosome (X(Delta)X) skews XCI toward the mutated X chromosome in the female soma. Here I have generated homozygous Tsix-null mice (X(Delta)X(Delta)) to test how deleting the second allele affects the choice of XCI. Homozygosity leads to extremely low fertility and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12145659
DOI: 10.1038/ng939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation.PMID 12145659Read ↗

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Effect of TSIX disruption on XIST expression in male ES cells.Semantic proximity Read ↗

A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice.Semantic proximity Read ↗

Tsix-deficient X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.Semantic proximity Read ↗

Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States.Semantic proximity Read ↗

Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation.Semantic proximity Read ↗

Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.Semantic proximity Read ↗

Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.Semantic proximity Read ↗

Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line.Semantic proximity Read ↗

Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification.Semantic proximity Read ↗

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