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Article

An absolute requirement for Cubitus interruptus in Hedgehog signaling.

Development (Cambridge, England) - 1 Mar 2001

Méthot N, Basler K

Abstract excerpt

Hedgehog (Hh) proteins play diverse organizing roles in animal development by regulating gene expression in responding cells. Several components of the Hh signal transduction pathway have been identified, yet their precise role in mediating the various outputs of the pathway is still poorly understood. The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Drosophila Hh target...

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PMID: 11171398
DOI: 10.1242/dev.128.5.733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An absolute requirement for Cubitus interruptus in Hedgehog signaling.PMID 11171398Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities.Semantic proximity Read ↗

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.Semantic proximity Read ↗

Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap.Semantic proximity Read ↗

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.Semantic proximity Read ↗

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Semantic proximity Read ↗

Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing.Semantic proximity Read ↗

Genetic dissection of the Drosophila Cubitus interruptus signaling complex.Semantic proximity Read ↗

Genetic and biochemical definition of the Hedgehog receptor.Semantic proximity Read ↗

A gain-of-function mutant of patched dissects different responses to the hedgehog gradient.Semantic proximity Read ↗

A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary.Semantic proximity Read ↗

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