Article
A gain-of-function mutant of patched dissects different responses to the hedgehog gradient.
Developmental biology - 15 Dec 2000
Mullor J L, Guerrero I
Abstract excerpt
The Hedgehog (Hh) signal has an inductive role during Drosophila development. Patched is part of the Hedgehog-receptor complex and shows a repressive function on the signaling cascade, which is alleviated in the presence of Hh. Herein, we identify the first dominant gain-of-function allele of patched, Confused (patched(Con)). Analysis of the patched(Con) allele led us to uncover novel features of the reception...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.