Article
A gain-of-function mutant of patched dissects different responses to the hedgehog gradient.
Developmental biology - 15 Dec 2000
Mullor J L, Guerrero I
Abstract excerpt
The Hedgehog (Hh) signal has an inductive role during Drosophila development. Patched is part of the Hedgehog-receptor complex and shows a repressive function on the signaling cascade, which is alleviated in the presence of Hh. Herein, we identify the first dominant gain-of-function allele of patched, Confused (patched(Con)). Analysis of the patched(Con) allele led us to uncover novel features of the reception...
Topics
- Alleles
- Animals
- Animals, Genetically Modified
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation, Developmental
- Genes, Reporter
- Hedgehog Proteins
- Homeodomain Proteins
- Insect Proteins
- Membrane Proteins
- Mutation
- Phenotype
- Receptors, Cell Surface
- Signal Transduction
- Transcription Factors
- Wings, Animal