Article
Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.
Cell - 19 Mar 1999
Méthot N, Basler K
Abstract excerpt
Hedgehog (Hh) proteins play diverse organizing roles in development by regulating gene expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Hh target genes. A repressor form of Ci arises in the absence of Hh signaling by proteolytic cleavage of intact Ci. We show that this cleavage is essential for limb patterning and is regulated by Hh in vivo....
Topics
- Alleles
- Animals
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Endopeptidases
- Extremities
- Gene Expression Regulation, Developmental
- Hedgehog Proteins
- Homeodomain Proteins
- Insect Proteins
- Repressor Proteins
- Trans-Activators
- Transcription Factors
- Transcription, Genetic
- Transgenes