Article
Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities.
Development (Cambridge, England) - 1 Oct 2000
Aza-Blanc P, Lin H Y, Ruiz i Altaba A, Kornberg T B
Abstract excerpt
The Cubitus interruptus (Ci) and Gli proteins are transcription factors that mediate responses to Hedgehog proteins (Hh) in flies and vertebrates, respectively. During development of the Drosophila wing, Ci transduces the Hh signal and regulates transcription of different target genes at different locations. In vertebrates, the three Gli proteins are expressed in overlapping domains and are partially redundant....
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