Article
Genetic dissection of the Drosophila Cubitus interruptus signaling complex.
Developmental biology - 15 Aug 2001
Lefers M A, Wang Q T, Holmgren R A
Abstract excerpt
Much of our understanding of the Hedgehog (Hh) signaling pathway comes from Drosophila, where a gradient of Hh signaling regulates the function of the transcription factor Cubitus interruptus (Ci) at three levels: protein stabilization, nuclear import, and activation. Regulation of Ci occurs in a cytoplasmic complex containing Ci, the kinesin-like protein Costal-2 (Cos2), the serine-threonine kinase Fused (Fu),...
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