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Article

Ci: a complex transducer of the hedgehog signal.

Trends in genetics : TIG - 1 Nov 1999

Aza-Blanc P, Kornberg T B

Abstract excerpt

Recent progress has unveiled Cubitus interruptus (Ci) as a complex transcription factor whose diverse activities as an activator and repressor are regulated by its proteolysis, localization and concentration. The principal role of Ci is to elaborate the developmental program directed by the morphogen Hedgehog (Hh), and it uses its various activities to target the expression of key downstream genes to different...

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Identifiers

PMID: 10529809
DOI: 10.1016/s0168-9525(99)01869-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ci: a complex transducer of the hedgehog signal.PMID 10529809Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

An absolute requirement for Cubitus interruptus in Hedgehog signaling.Semantic proximity Read ↗

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.Semantic proximity Read ↗

Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities.Semantic proximity Read ↗

Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap.Semantic proximity Read ↗

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.Semantic proximity Read ↗

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.Semantic proximity Read ↗

Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.Semantic proximity Read ↗

Genetic dissection of the Drosophila Cubitus interruptus signaling complex.Semantic proximity Read ↗

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.Semantic proximity Read ↗

Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing.Semantic proximity Read ↗

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.Semantic proximity Read ↗

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