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Article

Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing.

eLife - 21 Oct 2020

Little Jamie C, Garcia-Garcia Elisa, Sul Amanda, Kalderon Daniel

Abstract excerpt

Extracellular Hedgehog (Hh) proteins induce transcriptional changes in target cells by inhibiting the proteolytic processing of full-length Drosophila Ci or mammalian Gli proteins to nuclear transcriptional repressors and by activating the full-length Ci or Gli proteins. We used Ci variants expressed at physiological levels to investigate the contributions of these mechanisms to dose-dependent Hh signaling in...

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Identifiers

PMID: 33084577
DOI: 10.7554/eLife.61083
PMCID: PMC7679133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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