Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap.

doi:10.1242/dev.127.19.4095

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Article

Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap.

Development (Cambridge, England) - 1 Oct 2000

Campbell G L, Tomlinson A

Abstract excerpt

Members of the Hedgehog (HH) family of secreted signaling molecules specify cell fate during animal development by controlling the activity of members of the Gli family of zinc-finger transcription factors in responding cells. In Drosophila the Gli homolog, cubitus interruptus (CI), is expressed only in the anterior compartment where it represses targets such as the signaling molecule genes decapentaplegic (dpp)...

Topics

Alleles
Amino Acid Sequence
Animals
Body Patterning
DNA Transposable Elements
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Extremities
Gene Expression Regulation
Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hedgehog Proteins

Homeodomain Proteins

Insect Proteins

Molecular Sequence Data

Mutagenesis, Insertional

Mutation

Phenotype

Source

Open in PubMed

Identifiers

PMID: 10976042
DOI: 10.1242/dev.127.19.4095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10976042-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap.PMID 10976042Read ↗

The combgap locus encodes a zinc-finger protein that regulates cubitus interruptus during limb development in Drosophila melanogaster.Semantic proximity Read ↗

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