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Article

A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary.

Developmental biology - 1 Feb 2009

Devine Christine A, Sbrogna Jennifer L, Guner Burcu, Osgood Marcey, Shen Meng-Chieh, Karlstrom Rolf O

Abstract excerpt

Hedgehog (Hh) signaling is necessary for the induction and functional patterning of the pituitary placode, however the mechanisms by which Hh signals are interpreted by placodal cells are unknown. Here we show distinct temporal requirements for Hh signaling in endocrine cell differentiation and describe a dynamic Gli transcriptional response code that interprets these Hh signals within the developing...

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Identifiers

PMID: 19056374
DOI: 10.1016/j.ydbio.2008.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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