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Article

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.

Nature - 18 Dec 2008

Ogden Stacey K, Fei Dennis Liang, Schilling Neal S, Ahmed Yashi F, Hwa John, Robbins David J

Abstract excerpt

The hedgehog (Hh) signalling pathway has an evolutionarily conserved role in patterning fields of cells during metazoan development, and is inappropriately activated in cancer. Hh pathway activity is absolutely dependent on signalling by the seven-transmembrane protein smoothened (Smo), which is regulated by the Hh receptor patched (Ptc). Smo signals to an intracellular multi-protein complex containing the...

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Source

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Identifiers

PMID: 18987629
DOI: 10.1038/nature07459
PMCID: PMC2744466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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