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Article

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.

Nature - 17 Apr 1997

Akimaru H, Chen Y, Dai P, Hou D X, Nonaka M, Smolik S M, Armstrong S, Goodman R H, Ishii S

Abstract excerpt

The transcription factor CBP, originally identified as a coactivator for CREB, enhances transcription mediated by many other transcription factors. Mutations in the human CBP gene are associated with Rubinstein-Taybi syndrome, a haploinsufficiency disorder characterized by abnormal pattern formation, but the mechanism by which decreased CBP levels affect pattern formation is unclear. The hedgehog (hh) signalling...

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Identifiers

PMID: 9109493
DOI: 10.1038/386735a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.PMID 9109493Read ↗

Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap.Semantic proximity Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

A function of CBP as a transcriptional co-activator during Dpp signalling.Semantic proximity Read ↗

An absolute requirement for Cubitus interruptus in Hedgehog signaling.Semantic proximity Read ↗

Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome.Semantic proximity Read ↗

A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye.Semantic proximity Read ↗

Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities.Semantic proximity Read ↗

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.Semantic proximity Read ↗

The combgap locus encodes a zinc-finger protein that regulates cubitus interruptus during limb development in Drosophila melanogaster.Semantic proximity Read ↗

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.Semantic proximity Read ↗

The ciD mutation encodes a chimeric protein whose activity is regulated by Wingless signaling.Semantic proximity Read ↗

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