Article
Genetic and biochemical definition of the Hedgehog receptor.
Genes & development - 1 Jan 2010
Zheng Xiaoyan, Mann Randall K, Sever Navdar, Beachy Philip A
Abstract excerpt
Although the transporter-like protein Patched (Ptc) is genetically implicated in reception of the extracellular Hedgehog (Hh) protein signal, a clear definition of the Hh receptor is complicated by the existence of additional Hh-binding proteins and, in Drosophila, by the lack of physical evidence for direct binding of Hh to Ptc. Here we show that activity of Ihog (Interference hedgehog), or of its close relative...
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