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Article

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.

Mechanisms of development - 1 Jul 1995

Motzny C K, Holmgren R

Abstract excerpt

The segment polarity gene cubitus interruptus (ci) is required to maintain expression of the wingless gene and to specify naked cuticle within each epidermal segment. Antibodies were generated against the ci protein and used to analyze its pattern of expression. By stage 11, post-transcriptional regulation of ci is observed. ci transcript levels are uniform across the anterior compartment, but protein levels are...

Topics

Animals
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Gene Expression Regulation, Developmental
Hedgehog Proteins
Morphogenesis
Mutation
Proteins
Proto-Oncogene Proteins
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factors

Wnt1 Protein

Source

Identifiers

PMID: 7577671
DOI: 10.1016/0925-4773(95)00397-j

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7577671-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.PMID 7577671Read ↗

Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster.Semantic proximity Read ↗

An absolute requirement for Cubitus interruptus in Hedgehog signaling.Semantic proximity Read ↗

Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos.Semantic proximity Read ↗

Genetic dissection of the Drosophila Cubitus interruptus signaling complex.Semantic proximity Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap.Semantic proximity Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.Semantic proximity Read ↗

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells.Semantic proximity Read ↗

The ciD mutation encodes a chimeric protein whose activity is regulated by Wingless signaling.Semantic proximity Read ↗

A gain-of-function mutant of patched dissects different responses to the hedgehog gradient.Semantic proximity Read ↗

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.Semantic proximity Read ↗

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