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Article

Sir2 mediates longevity in the fly through a pathway related to calorie restriction.

Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2004

Rogina Blanka, Helfand Stephen L

Abstract excerpt

Calorie restriction can extend life span in a variety of species including mammals, flies, nematodes, and yeast. Despite the importance of this nearly universal effect, little is understood about the molecular mechanisms that mediate the life-span-extending effect of calorie restriction in metazoans. Sir2 is known to be involved in life span determination and calorie restriction in yeast mother cells. In...

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Identifiers

PMID: 15520384
DOI: 10.1073/pnas.0404184101
PMCID: PMC528752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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