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Article

Glutathione is necessary to ensure benefits of calorie restriction during ageing in Saccharomyces cerevisiae.

Mechanisms of ageing and development - 1 Dec 2008

Mannarino Sérgio C, Amorim Maria A, Pereira Marcos D, Moradas-Ferreira Pedro, Panek Anita D, Costa Vítor, Eleutherio Elis C A

Abstract excerpt

Calorie restriction increases longevity of mammals and yeasts but this mechanism remains unclear. In this study, the role of glutathione on lifespan extension induced by calorie restriction was investigated by using a Saccharomyces cerevisiae strain deficient in glutathione synthesis (gsh1). We observed an increase in chronological lifespan of calorie-restricted gsh1 mutant cells, compared to WT (wild type)...

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Identifiers

PMID: 18840459
DOI: 10.1016/j.mad.2008.09.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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