Glutathione is necessary to ensure benefits of calorie restriction during ageing in Saccharomyces cerevisiae.

doi:10.1016/j.mad.2008.09.001

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Article

Glutathione is necessary to ensure benefits of calorie restriction during ageing in Saccharomyces cerevisiae.

Mechanisms of ageing and development - 1 Dec 2008

Mannarino Sérgio C, Amorim Maria A, Pereira Marcos D, Moradas-Ferreira Pedro, Panek Anita D, Costa Vítor, Eleutherio Elis C A

Abstract excerpt

Calorie restriction increases longevity of mammals and yeasts but this mechanism remains unclear. In this study, the role of glutathione on lifespan extension induced by calorie restriction was investigated by using a Saccharomyces cerevisiae strain deficient in glutathione synthesis (gsh1). We observed an increase in chronological lifespan of calorie-restricted gsh1 mutant cells, compared to WT (wild type)...

Topics

Aconitate Hydratase
Antioxidants
Culture Media
Genes, Fungal
Glucosephosphate Dehydrogenase
Glutamate-Cysteine Ligase
Glutathione
Glutathione Reductase
Models, Biological
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidative Stress

Oxygen Consumption

Protein Carbonylation

Pyruvate Kinase

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 18840459
DOI: 10.1016/j.mad.2008.09.001

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