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Article

Life span extension and neuronal cell protection by Drosophila nicotinamidase.

The Journal of biological chemistry - 10 Oct 2008

Balan Vitaly, Miller Gregory S, Kaplun Ludmila, Balan Karina, Chong Zhao-Zhong, Li Faqi, Kaplun Alexander, VanBerkum Mark F A, Arking Robert, Freeman D Carl, Maiese Kenneth, Tzivion Guri

Abstract excerpt

The life span of model organisms can be modulated by environmental conditions that influence cellular metabolism, oxidation, or DNA integrity. The yeast nicotinamidase gene pnc1 was identified as a key transcriptional target and mediator of calorie restriction and stress-induced life span extension. PNC1 is thought to exert its effect on yeast life span by modulating cellular nicotinamide and NAD levels,...

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Identifiers

PMID: 18678867
DOI: 10.1074/jbc.M804681200
PMCID: PMC2562057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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