Article
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.
Molecular cell - 1 Feb 2000
Mumm J S, Schroeter E H, Saxena M T, Griesemer A, Tian X, Pan D J, Ray W J, Kopan R
Abstract excerpt
Gamma-secretase-like proteolysis at site 3 (S3), within the transmembrane domain, releases the Notch intracellular domain (NICD) and activates CSL-mediated Notch signaling. S3 processing occurs only in response to ligand binding; however, the molecular basis of this regulation is unknown. Here we demonstrate that ligand binding facilitates cleavage at a novel site (S2), within the extracellular juxtamembrane...
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