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Article

An Overview of Notch Signaling in Adult Tissue Renewal and Maintenance

1 Feb 2012

Abstract excerpt

The Notch pathway is a critical mediator of short-range cell-cell communication that is reiteratively used to regulate a diverse array of cellular processes during embryonic development and the renewal and maintenance of adult tissues. Most Notch-dependent processes utilize a core signaling mechanism that is dependent on regulated intramembrane proteolysis: Upon ligand binding, Notch receptors undergo ectodomain...

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PMID: 21605032
DOI: 10.2174/156720512799361600

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