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Article

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.

Molecular and cellular biology - 1 Jan 2008

Tagami Shinji, Okochi Masayasu, Yanagida Kanta, Ikuta Akiko, Fukumori Akio, Matsumoto Naohiko, Ishizuka-Katsura Yoshiko, Nakayama Taisuke, Itoh Naohiro, Jiang Jingwei, Nishitomi Kouhei, Kamino Kouzin, Morihara Takashi, Hashimoto Ryota, Tanaka Toshihisa, Kudo Takashi, Chiba Shigeru, Takeda Masatoshi

Abstract excerpt

Intramembrane proteolysis by presenilin-dependent gamma-secretase produces the Notch intracellular cytoplasmic domain (NCID) and Alzheimer disease-associated amyloid-beta. Here, we show that upon Notch signaling the intracellular domain of Notch-1 is cleaved into two distinct types of NICD species due to diversity in the site of S3 cleavage. Consistent with the N-end rule, the S3-V cleavage produces stable NICD...

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Identifiers

PMID: 17967888
DOI: 10.1128/MCB.00863-07
PMCID: PMC2223315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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