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Article

Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.

PloS one - 24 Aug 2009

Gordon Wendy R, Vardar-Ulu Didem, L'Heureux Sarah, Ashworth Todd, Malecki Michael J, Sanchez-Irizarry Cheryll, McArthur Debbie G, Histen Gavin, Mitchell Jennifer L, Aster Jon C, Blacklow Stephen C

Abstract excerpt

BACKGROUND: Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR) of the receptor, which contains three highly conserved Lin12/Notch repeats and a heterodimerization domain (HD) that interact to prevent premature signaling in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19701457
DOI: 10.1371/journal.pone.0006613
PMCID: PMC2726630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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