Article

γ-Secretase-mediated endoproteolysis of neuregulin-1 and E-cadherin

2025-04-19

Abstract excerpt

<h4>ABSTRACT</h4> γ-Secretase is an intramembrane protease complex, with nearly 150 substrates that are cleaved within their transmembrane domains (TMD). Amyloid Precursor Protein (APP) is the most widely studied, as processive proteolysis by γ-secretase releases the amyloid-β-peptide (Aβ) implicated in the pathogenesis of Alzheimer’s disease. In contrast, proteolysis of other substrates has been little explored....

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Literature Corpus work: b2b89a3b-1746-5497-81af-3529baf315c9
DOI: 10.1101/2025.04.19.649652

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