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Article

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

The Journal of biological chemistry - 1 Jan 2016

Fleck Daniel, Voss Matthias, Brankatschk Ben, Giudici Camilla, Hampel Heike, Schwenk Benjamin, Edbauer Dieter, Fukumori Akio, Steiner Harald, Kremmer Elisabeth, Haug-Kröper Martina, Rossner Moritz J, Fluhrer Regina, Willem Michael, Haass Christian

Abstract excerpt

Numerous membrane-bound proteins undergo regulated intramembrane proteolysis. Regulated intramembrane proteolysis is initiated by shedding, and the remaining stubs are further processed by intramembrane-cleaving proteases (I-CLiPs). Neuregulin 1 type III (NRG1 type III) is a major physiological substrate of β-secretase (β-site amyloid precursor protein-cleaving enzyme 1 (BACE1)). BACE1-mediated cleavage is...

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Identifiers

PMID: 26574544
DOI: 10.1074/jbc.M115.697995
PMCID: PMC4697167

Genes

NRG1
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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