Article
Notch receptor cleavage depends on but is not directly executed by presenilins.
Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002
Taniguchi Yoshihito, Karlström Helena, Lundkvist Johan, Mizutani Tomohiko, Otaka Akira, Vestling Monica, Bernstein Alan, Donoviel Dorit, Lendahl Urban, Honjo Tasuku
Abstract excerpt
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling. This so-called gamma-secretase cleavage is under the control of presenilins, but it is not known whether presenilins themselves carry out the cleavage...
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