Proteolytic cleavage of Notch: "HIT and RUN".

doi:10.2174/156652411795677972

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Article

Proteolytic cleavage of Notch: "HIT and RUN".

Current molecular medicine - 1 Jun 2011

van Tetering G, Vooijs M

Abstract excerpt

The Notch pathway is a highly conserved signaling pathway in multicellular eukaryotes essential in controlling spatial patterning, morphogenesis and homeostasis in embryonic and adult tissues. Notch proteins coordinate cell-cell communication through receptor-ligand interactions between adjacent cells. Notch signaling is frequently deregulated by oncogenic mutation or overexpression in many cancer types. Notch...

Topics

ADAM Proteins
Amyloid Precursor Protein Secretases
Animals
Cell Communication
Embryonic Development
Eukaryota
Furin
Gene Expression Regulation
Homeostasis
Humans
Morphogenesis
Mutation
Neoplasms
Oligopeptides
Presenilins
Receptors, Notch
Signal Transduction
Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 21506924
DOI: 10.2174/156652411795677972
PMCID: PMC4050734

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