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Article

Nuclear access and action of notch in vivo.

Cell - 15 May 1998

Struhl G, Adachi A

Abstract excerpt

The Drosophila Notch (N) gene encodes a conserved single-pass transmembrane receptor that transduces extracellular signals controlling cell fate. Here, we present evidence that the intracellular domain of Notch gains access to the nucleus in response to ligand, possibly through a mechanism involv...

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Identifiers

PMID: 9604939
DOI: 10.1016/s0092-8674(00)81193-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9604939-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Nuclear access and action of notch in vivo.PMID 9604939Read ↗

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Proteolytic cleavage of Notch: "HIT and RUN".Semantic proximity Read ↗

Notch signaling: control of cell communication and cell fate.Semantic proximity Read ↗

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.Semantic proximity Read ↗

Notch signaling.Semantic proximity Read ↗

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.Semantic proximity Read ↗

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.Semantic proximity Read ↗

An Overview of Notch Signaling in Adult Tissue Renewal and MaintenanceSemantic proximity Read ↗

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila.Semantic proximity Read ↗

Notch and disease: a growing field.Semantic proximity Read ↗

Notch receptor cleavage depends on but is not directly executed by presenilins.Semantic proximity Read ↗

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.Semantic proximity Read ↗

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