Article

Size-dependent protein segregation creates a spatial switch for Notch signaling and function

2020-06-29

Abstract excerpt

Aberrant cleavage of Notch by γ-secretase is implicated in numerous diseases, but how cleavage is regulated in space and time is unclear. Here, we report that cadherin-based adherens junctions (cadAJs) are sites of high cell-surface γ-secretase activity, as well as sites of constrained physical space that excludes γ-secretase substrates having large extracellular domains (ECDs) like Notch. ECD shedding initiates d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cef317ab-82d6-5d4b-be72-76329634d8ff
DOI: 10.1101/2020.06.28.176560

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Size-dependent protein segregation creates a spatial switch for Notch signaling and functionDOI 10.1101/2020.06.28.176560Read

Membrane compartmentalization by adherens junctions creates a spatial switch for Notch signaling and functionSemantic proximity Read

γ-Secretase-mediated endoproteolysis of neuregulin-1 and E-cadherinSemantic proximity Read

Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complexSemantic proximity Read

Effects of transmembrane phenylalanine residues on γ-secretase-mediated Notch-1 proteolysisSemantic proximity Read

Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.Semantic proximity Read

Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by γ-Secretase.Semantic proximity Read

Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.Semantic proximity Read

Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycanSemantic proximity Read

Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.Semantic proximity Read

An atomic structure of human γ-secretase.Semantic proximity Read

How amyloid precursor protein protects itself from cleavage.Semantic proximity Read

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.Semantic proximity Read