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Article

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

The EMBO journal - 15 Oct 2002

Okochi Masayasu, Steiner Harald, Fukumori Akio, Tanii Hisashi, Tomita Taisuke, Tanaka Toshihisa, Iwatsubo Takeshi, Kudo Takashi, Takeda Masatoshi, Haass Christian

Abstract excerpt

Following ectodomain shedding, Notch-1 undergoes presenilin (PS)-dependent constitutive intramembranous endoproteolysis at site-3. This cleavage is similar to the PS-dependent gamma-secretase cleavage of the beta-amyloid precursor protein (betaAPP). However, topological differences in cleavage re...

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Identifiers

PMID: 12374741
DOI: 10.1093/emboj/cdf541
PMCID: PMC129073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12374741-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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