Article

Effects of transmembrane phenylalanine residues on γ-secretase-mediated Notch-1 proteolysis

2024-12-11

Abstract excerpt

<h4>ABSTRACT</h4> γ-Secretase is a presenilin-containing intramembrane aspartyl protease complex that cleaves within the transmembrane domain (TMD) of nearly 150 substrates, with the amyloid precursor protein (APP) being the most well studied. APP cleavage by γ-secretase generates amyloid β-peptides (Aβ) that pathologically deposit in Alzheimer’s disease. APP TMD substrate undergoes initial endoproteolysis (ε-cle...

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Literature Corpus work: cbb50f36-316e-5630-a8cc-fdd83405c560
DOI: 10.1101/2024.12.11.628002

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