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Article

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.

Neuroreport - 16 Dec 1999

Tsai S J, Hong C J, Wang Y C

Abstract excerpt

Serotonergic dysfunction is implicated in mood disorders and suicidal behaviors. Genetic variants of tryptophan hydroxylase (TPH), a rate-limiting enzyme in the biosynthesis of serotonin, were associated with suicidal behaviors in three reports, but were not found in other studies. We investigated the TPH A218C polymorphism in 151 subjects with mood disorders and 200 control subjects. The results demonstrated a...

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Source

Identifiers

PMID: 10716208
DOI: 10.1097/00001756-199912160-00010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.PMID 10716208Read ↗

Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis.Semantic proximity Read ↗

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Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis.Semantic proximity Read ↗

TPH1 A218 allele is associated with suicidal behavior in Turkish population.Semantic proximity Read ↗

TPH gene may be associated with suicidal behavior, but not with schizophrenia in the Korean population.Semantic proximity Read ↗

Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis.Semantic proximity Read ↗

Association between the tryptophan hydroxylase gene and manic-depressive illness.Semantic proximity Read ↗

Increased risk of suicide attempt in mood disorders and TPH1 genotype.Semantic proximity Read ↗

Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls.Semantic proximity Read ↗

Serotonergic genes and suicide: a systematic review.Semantic proximity Read ↗

No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients.Semantic proximity Read ↗

Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses.Semantic proximity Read ↗

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