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Article

Investigation of A218C tryptophan hydroxylase polymorphism: association with familial suicide behavior and proband's suicide attempt characteristics.

Genes, brain, and behavior - 1 Jun 2006

Viana M M, De Marco L A, Boson W L, Romano-Silva M A, Corrêa H

Abstract excerpt

According to WHO, suicide accounts for about 1,000,000 deaths worldwide every year. In view of these dramatic data, several studies have tried to identify possible biological mechanisms and markers of suicide. Genes encoding for proteins involved in the serotonergic transmission are major candidates in association studies of suicidal behavior. The gene that codes for tryptophan hydroxylase (TPH), the...

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Identifiers

PMID: 16716203
DOI: 10.1111/j.1601-183X.2005.00171.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Investigation of A218C tryptophan hydroxylase polymorphism: association with familial suicide behavior and proband's suicide attempt characteristics.PMID 16716203Read ↗

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Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis.Semantic proximity Read ↗

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.Semantic proximity Read ↗

TPH1 A218 allele is associated with suicidal behavior in Turkish population.Semantic proximity Read ↗

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Case control and family-based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents.Semantic proximity Read ↗

The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case-control study and meta-analysis.Semantic proximity Read ↗

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TPH gene may be associated with suicidal behavior, but not with schizophrenia in the Korean population.Semantic proximity Read ↗

Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls.Semantic proximity Read ↗

Tryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individuals.Semantic proximity Read ↗

Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses.Semantic proximity Read ↗

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