Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses.

Abstract excerpt

Suicide is a major public health issue, especially in western countries, accounting for approximately 1 million deaths every year throughout the world. The tryptophan hydroxylase (TPH) gene has been extensively studied as a candidate for suicidal behavior due to its role in serotonergic neurotransmission. Since the first study associating the gene with schizophrenia, there have been many attempts to replicate it....

Topics

• Gene Frequency
• Genotype
• Humans
• Polymorphism, Genetic
• Retrospective Studies
• Sensitivity and Specificity
• Suicide
• Tryptophan Hydroxylase