Article
Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls.
Molecular psychiatry - 1 Jan 2002
Ono H, Shirakawa O, Kitamura N, Hashimoto T, Nishiguchi N, Nishimura A, Nushida H, Ueno Y, Maeda K
Abstract excerpt
Several lines of evidence suggest that a partly genetically controlled serotonergic dysfunction is involved in the biological pathogenesis of suicide. In this study, we measured tryptophan hydroxylase (TPH) immunoreactivity as a pre-synaptic marker, and serotonin receptor 2A (5HT2A receptor) density as a post-synaptic marker in the serotonergic system in 10 postmortem brains of suicide victims. We also examined...
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