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Article

Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis.

Biological psychiatry - 15 Aug 2003

Rujescu Dan, Giegling Ina, Sato Tetsuya, Hartmann Annette M, Möller Hans Jürgen

Abstract excerpt

BACKGROUND: Neurobiological studies implicate serotonergic dysfunction in suicidal behavior. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital role in serotonin metabolism. Thus, variations in the TPH gene have been regarded as prime candidates in the susceptibility to suicidal behavior. The most widely studied genetic variations in the TPH gene, which are...

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PMID: 12915291
DOI: 10.1016/s0006-3223(02)01748-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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