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Article

Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis.

Biological psychiatry - 15 Aug 2003

Rujescu Dan, Giegling Ina, Sato Tetsuya, Hartmann Annette M, Möller Hans Jürgen

Abstract excerpt

BACKGROUND: Neurobiological studies implicate serotonergic dysfunction in suicidal behavior. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital role in serotonin metabolism. Thus, variations in the TPH gene have been regarded as prime candidates...

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PMID: 12915291
DOI: 10.1016/s0006-3223(02)01748-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12915291-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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