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Article

TPH gene may be associated with suicidal behavior, but not with schizophrenia in the Korean population.

Human heredity - 1 Jan 2000

Paik I, Toh K, Kim J, Lee C

Abstract excerpt

Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the biosynthesis of serotonin. This study was designed to examine whether A218C polymorphism, which has been identified in intron 7 of the TPH gene, may be associated with schizophrenia or the suicidal behavior of schizophrenics in the Korean population. TPH genotypes were determined in DNA samples from 217 schizophrenics and 236 healthy volunteers. Among...

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PMID: 10899755
DOI: 10.1159/000022942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TPH gene may be associated with suicidal behavior, but not with schizophrenia in the Korean population.PMID 10899755Read ↗

The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case-control study and meta-analysis.Semantic proximity Read ↗

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.Semantic proximity Read ↗

TPH1 A218 allele is associated with suicidal behavior in Turkish population.Semantic proximity Read ↗

Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis.Semantic proximity Read ↗

Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses.Semantic proximity Read ↗

Investigation of A218C tryptophan hydroxylase polymorphism: association with familial suicide behavior and proband's suicide attempt characteristics.Semantic proximity Read ↗

Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis.Semantic proximity Read ↗

Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis.Semantic proximity Read ↗

Tryptophan hydroxylase gene polymorphisms are not associated with suicide.Semantic proximity Read ↗

Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide.Semantic proximity Read ↗

Tryptophan hydroxylase polymorphisms in suicide victims.Semantic proximity Read ↗

No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients.Semantic proximity Read ↗

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