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Article

Association between the tryptophan hydroxylase gene and manic-depressive illness.

Archives of general psychiatry - 1 Jan 1998

Bellivier F, Leboyer M, Courtet P, Buresi C, Beaufils B, Samolyk D, Allilaire J F, Feingold J, Mallet J, Malafosse A

Abstract excerpt

BACKGROUND: Genes encoding proteins involved in serotonergic metabolism are major candidates in association studies of mood disorders and suicidal behavior. This association study explores whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme of serotonin biosynt...

Topics

Adult
Alleles
Bipolar Disorder
Disease Susceptibility
Female
Gene Frequency
Genetic Markers
Genotype
Humans
Introns
Male
Middle Aged
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serotonin

Suicide

Suicide, Attempted

Tryptophan Hydroxylase

Violence

Source

Identifiers

PMID: 9435758
DOI: 10.1001/archpsyc.55.1.33

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9435758-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Association between the tryptophan hydroxylase gene and manic-depressive illness.PMID 9435758Read ↗

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.Semantic proximity Read ↗

Increased risk of suicide attempt in mood disorders and TPH1 genotype.Semantic proximity Read ↗

The tryptophan hydroxylase gene influences risk for bipolar disorder but not major depressive disorder: results of meta-analyses.Semantic proximity Read ↗

No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior.Semantic proximity Read ↗

Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder.Semantic proximity Read ↗

Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study.Semantic proximity Read ↗

No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients.Semantic proximity Read ↗

Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population.Semantic proximity Read ↗

Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.Semantic proximity Read ↗

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.Semantic proximity Read ↗

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