Article
No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients.
The American journal of psychiatry - 1 May 1999
Kunugi H, Ishida S, Kato T, Sakai T, Tatsumi M, Hirose T, Nanko S
Abstract excerpt
OBJECTIVE: Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin. The authors examined whether polymorphisms A218C and A779C in intron 7 of the tryptophan hydroxylase gene are associated with a risk for affective disorders or suicidal behavior. METHOD: Subjects were 141 patients with bipolar disorder and 73 patients with unipolar affective disorder, 46 of whom had a history of...
Topics
- Adult
- Alleles
- Asian People
- Bipolar Disorder
- Depressive Disorder
- Female
- Genotype
- Humans
- Introns
- Japan
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Suicide, Attempted